Beschreibung
Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician's fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual's susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain-machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
Inhaltsverzeichnis
Analysis of Combinatorial Gene Regulation with Thermodynamic Models Chieh-Chun Chen and Sheng Zhong RNA Secondary Structure Prediction and Gene Regulation by Small RNAs Ye Ding Some Critical Data Quality Control Issues of Oligoarrays Wenjiang J. Fu, Ming Li, Yalu Wen and Likit Preeyanon Stochastic-process Approach to Nonequilibrium Thermodynamics and Biological Signal Transduction Hao Ge Granger Causality: Theory and Applications Shuixia Guo, Christophe Ladroue and Jianfeng Feng Transcription Factor Binding Site Identification by Phylogenetic Footprinting Haiyan Hu and Xiaoman Li Learning Network from High-dimensional Array Data Li Hsu, Jie Peng and Pei Wang Computational Methods for Predicting Domain-Domain Interactions Hyunju Lee, Ting Chen and Fengzhu Sun Irreversible Stochastic Processes, Coupled Diffusions and Systems Biochemistry Pei-Zhe Shi and Hong Qian Probability Modeling and Statistical Inference in Periodic Cancer Screening Dongfeng Wu and Gary L. Rosner On Construction of the Smallest One-sided Confidence Intervals and its Application in Identifying the Minimum Effective Dose Weizhen Wang Group Variable Selection Methods and Their Applications in Analysis of Genomic Data Jun Xie and Lingmin Zeng Modeling Protein-Signaling Networks with Granger Causality Test Wenqiang Yang and Qiang Luo DNA Copy Number Profiling in Normal and Tumor Genomes Nancy R. Zhang Spatial Disease Surveillance: Methods and Applications Tonglin Zhang From QTL Mapping to eQTL Analysis Wei Zhang and Jun S Liu An Evaluation of Gene Module Concepts in the Interpretation of Gene Expression Data Xianghua Zhang and Hongyu Zhao Readout of Spike Waves in a Microcolumn Xuejuan Zhang False Positive Control for Genome-wide ChIP-chip Tiling Arrays Yu Zhang
