Beschreibung
The centrosome, the main microtubule organizing center, because of the 9-fold symmetry and the conserved stereotyped geometry of its centrioles, their peculiar (likely unique) orthogonal configuration in S/G2 phase, and their circumferential polarity (the triplets are different and non-equivalent) may play the role of a molecular interface, composed of two orthogonal "9-graduated centrioles/protractors", that recognizes and decodes topogenic targeting sequences and translates them by connecting each one with the corresponding correctly oriented microtubule: targeted molecular complexes (polarity factors, transmembrane receptors, mRNAs) can be delivered into their expected real locations in the cell. The centrosome operates as a spherical reference system organizer, capable of mapping and wiring the cell cortex, polarizing it in detail (fine-tuned polarity) generating a univocal one-to-one correspondence between centrosomal and cortical compartments. One of the two centrioles, named mother, if reversely rotationally polarized, likely constitutes the base for bilateral symmetry.
Autorenporträt
Engineer (Turin Institute of Technology) and Audiologist. Director of AudioLogic Department of Bioengineering and Mathematical modeling. Italian Journal of Anatomy and Embryology has published in 2013 his work "Centrosome: is it a geometric, noise resistant, 3D interface that translates morphogenetic signals into precise locations in the cell?"
