Beschreibung
his book is devoted to vascular endothelial growth factor A (VEGF his book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for or VEGFA), a secreted signalling protein of great significance for T development and disease in vertebrates. VEGFAcontrols the prolif Tdevelopment and disease in vertebrates. VEGFA controls the prol- eration, eration, migration migration, specialisatio specialisation n and and surviva survival l of vascula ofvascular r endothelia endothelial l cells, cells, and and iit t isis therefor therefore e essentia essential l for th for e establishmen the establishment t of a functiona ofa functional l blood vesse blood l vessel circuit. circuit. IIn n addition addition, VEGF VEGFA A is emergin is emerging g as a versatil as a versatile e patternin patterning g factor fofactor r for several several non endothelia non-endothelial l celcell l type types s in vertebrates in vertebrates. ThusThus, it playit s a centra plays al rol central e role during organ development at multiple levels, including blood vessel growth, duringorgan developmentat multiple levels, including blood vessel growth, vessel-mediated vessel mediated orga organ n inductio induction n andand tissutissue e differentiation differentiation. The The discover discovery y ofof non endothelia non-endothelial l rolesroles for VEGF for VEGFA A initiallinitially y came ascarne a as a surprise. surprise.
Inhaltsverzeichnis
1. The Biology of Vascular Endothelial Cell Growth Factor Isoforms Yin-Shan Ng 2. VEGF Receptor Signalling in Vertebrate Development Joaquim Miguel Vieira, Christiana Ruhrberg and Quenten Schwarz 3. VEGF Gene Regulation Marcus Fruttiger 4. Embryonic Vasculogenesis and Hematopoietic Specification Lauren C. Goldie, Melissa K. Nix and Karen K. Hirschi 5. Role of VEGF in Organogenesis Jody J. Haigh 6. VEGF and Endothelial Guidance in Angiogenic Sprouting Holger Gerhardt 7. Vascular and Nonvascular Roles of VEGF in Bone Development Christa Maes and Geert Carmeliet 8. VEGF in the Nervous System Jeffrey M. Rosenstein, Janette M. Krum and Christiana Ruhrberg
