Protein Structure, Stability, and Folding

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Methods in Molecular Biology 168

ISBN: 0896036820
ISBN 13: 9780896036826
Herausgeber: Kenneth P Murphy
Verlag: Humana Press
Umfang: ix, 252 S., 48 s/w Illustr., 5 s/w Fotos, 43 s/w Zeichng.
Erscheinungsdatum: 01.04.2001
Auflage: 1/2001
Produktform: Gebunden/Hardback
Einband: GEB

With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.

Artikelnummer: 1527163 Kategorie:

Beschreibung

InhaltsangabeStabilization of Protein Structure Kenneth P. Murphy Protein Stabilization by Naturally Occurring Osmolytes D. Wayne Bolen The Thermodynamic Linkage Between Protein Structure, Stability, and Function Ernesto Freire Measuring the Conformational Stability of a Protein by Hydrogen Exchange Beatrice M.P. Huyghues-Despointes, C. Nick Pace, S. Walter Englander, and J. Martin Scholtz Modeling the Native State Ensemble Vincent J. Hilser Conformational Entropy in Protein Folding: A Guide to Estimating Conformational Entropy via Modeling and Computation Trevor P. Creamer Turn Scanning: Experimental and Theoretical Approaches to the Role of Turns Carl Frieden, Enoch S. Huang, and Jay W. Ponder Laser Temperature-Jump Methods for Studying Folding Dynamics James Hofrichter Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins T. Sivaraman and Andrew D. Robertson Molecular Dynamics Simulations of Protein Unfolding/Folding Valerie Daggett

Inhaltsverzeichnis

Stabilization of Protein Structure Kenneth P. Murphy Protein Stabilization by Naturally Occurring Osmolytes D. Wayne Bolen The Thermodynamic Linkage Between Protein Structure, Stability, and Function Ernesto Freire Measuring the Conformational Stability of a Protein by Hydrogen Exchange Beatrice M.P. Huyghues-Despointes, C. Nick Pace, S. Walter Englander, and J. Martin Scholtz Modeling the Native State Ensemble Vincent J. Hilser Conformational Entropy in Protein Folding: A Guide to Estimating Conformational Entropy via Modeling and Computation Trevor P. Creamer Turn Scanning: Experimental and Theoretical Approaches to the Role of Turns Carl Frieden, Enoch S. Huang, and Jay W. Ponder Laser Temperature-Jump Methods for Studying Folding Dynamics James Hofrichter Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins T. Sivaraman and Andrew D. Robertson Molecular Dynamics Simulations of Protein Unfolding/Folding Valerie Daggett

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