Beschreibung
A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.
Inhaltsverzeichnis
Foreword. Schizophrenia Spectrum Disorders: Insights from views across 100 years.- 1. The schizophrenia construct after 100 years of challenges.- 2. Diagnosis and classification of the schizophrenia spectrum disorders.- 3. Toward Multidimensional Continuum Model of functional psychoses for research purposes.- 4. Irving Gottesman and the schizophrenia spectrum.- 5. Schizotypy: Reflections on the bridge to schizophrenia and obstacles on the road ahead to etiology and pathogenesis.- 6. Autism spectrum disorders and schizophrenia.- 7. One hundred years of insanity: genomic, psychological, and evolutionary models of autism in relation to schizophrenia.- 8. Quantifying the dynamics of central systemic degeneration in schizophrenia.- 9. Schizophrenia runs in some families, but where are the genes?- 10. Changes in gene expression in subjects with schizophrenia associated with disease progression.- 11. Amino acids in schizophrenia -- glycine, serine and arginine.- 12. Developmental consequences of prenatal immune activation.- 13. Glutamatergic neurotransmission abnormalities and schizophrenia.- 14. Mathematical models in schizophrenia.- 15. Methamphetamine psychosis: a model for biomarker discovery in schizophrenia.- 16. What does proteomics tell us about schizophrenia?- 17. The role of 3α-hydroxy-5α-pregnan-20-one in mediating the development and/or expression of schizophrenia spectrum disorders: Findings in rodents models and clinical populations.- 18. Neural substrates of emotion dysfunctions in patients with schizophrenia spectrum disorders.- 19. Brain morphological abnormalities at the onset of schizophrenia and other psychotic disorders. A review of the evidence.- 20. Mapping prodromal psychosis.- Afterword. The future of the schizophrenia construct and acquisition of new knowledge.
