Cell Engineering and Regeneration

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748,99 

Tissue Engineering – 2 Bde, Reference Series in Biomedical Engineering – Tissue Engineering and Regeneration

ISBN: 3319088300
ISBN 13: 9783319088303
Herausgeber: Jeffrey M Gimble/Darja Marolt Presen/Richard O C Oreffo et al
Verlag: Springer Verlag GmbH
Umfang: xxvi, 800 S., 5 s/w Illustr., 81 farbige Illustr., 800 p. 86 illus., 81 illus. in color.
Erscheinungsdatum: 19.08.2020
Auflage: 1/2020
Produktform: Gebunden/Hardback
Einband: GEB

Covers the use of autologous versus allogeneic cell sourcesExplores procedures for cell isolation and pre-conditioningIncludes contributions from the TERMIS communityIncludes supplementary material: sn.pub/extras

Artikelnummer: 6833018 Kategorie:

Beschreibung

InhaltsangabeSources.- Primary cells.- Chondrocytes.- Muscle cells.- ß-cells.- Schwann cells.- Cell lines for test systems.- Immortalized primary cells.- STEM.- Bone marrow derived.- Placenta derived cells.- Amnion.- in toto.- Placenta / Chorion.- Cord/Wharton cells.- Amniotic fluid cells.- Adipose derived cells.- Isolation enzymatic.- SVF.- Isolation non-enzymatic.- SVF.- ASC.- Perivascular / Angiogenic cells origin.- Multiple Sources.- Blood.- Olfactory mucosa.- Tendon.- iPS, ES or Transdifferentiation.- ESC.- Many sources and routes to iPS.- Needs for clinical application.- Tools for mechanistic studies.- HaploBank.- Autologous or Allogeneic.- Preconditioning.- Sorting.- Biophysical.- Chemical.- Transfection.- Aggregation.- Sheets.- Microaggregates.- Two level approach.- Modulation.- Growth factors.- miRNA.- Epigenetic approaches.- Biophysical.- Two level approach.- "Student-Teacher".- Coculture.- "Student-School".- Environmental Cues.- Application Routes.- Systemic.- Local.- Endogenous catching.- SDF-1-CXCR4 axis.- Cell Tracking.- Action.- Cell differentiation.- Cell-cell contact.- Secretome.- Learning from embryogenesis / evolution.- Basics of amphibian self regeneration.

Autorenporträt

Dr. Gimble is Co-founder and Chief Scientific Officer of LaCell LLC and Obatala Sciences Inc. For over 30 years, Dr. Gimble's laboratory has focused on stromal/stem cells isolated from bone marrow and adipose tissue as a model system for differentiation, hematopoiesis, metabolism, and regenerative medicine. Over this period, he has held faculty appointments (full time or adjunct) at the Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Baylor College of Medicine, University of North Carolina Chapel Hill, Duke University Medical Center, Louisiana State University Health Sciences Center New Orleans, and Tulane University Center for Stem Cell Research and Regenerative Medicine. In addition, Dr. Gimble spent 4 years in the Research Triangle Park, NC, at Zen-Bio, Inc., a biotechnology company supplying human primary adipose-derived cells to the research community (1999-2000), and at Artecel Sciences, a tissue engineering company that he co-founded and helped lead as Chief Scientific Officer (2000-2003). Dr. Darja Marolt Presen completed her doctoral studies at the University of Ljubljana, Slovenia, and was a visiting Ph.D. student at the Massachusetts Institute of Technology, Boston, USA. She trained as a postdoctoral scientist at Columbia University, New York, USA, and was leading the bone regeneration group at the New York Stem Cell Foundation Research Institute, New York, USA. She is currently the principal investigator of the bone bioengineering and regeneration group at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in Vienna, Austria. Her research in bone tissue engineering and regeneration was supported by fellowships and grants from the Republic of Slovenia, New York Stem Cell Foundation, FFG Austria, and European Commission (Horizon 2020). Richard O. C. Oreffo is Professor of Musculoskeletal Science and Co-founder/Director of the Centre for Human Development, Stem Cells and Regeneration at the University of Southampton. He leads a multidisciplinary research group focused on developing strategies to repair bone and cartilage, with translation a key personal driver. To achieve these goals, he has brought together and developed teams of clinicians/life scientists over the last 20 years and trained 47 M.D./Ph.D. students to completion, to date. He has published more than 300 peer-reviewed paper including breakthrough publications on skeletal stem cells and nanotopography, bone regeneration, as well as epigenetics and holds 6 patents. Richard is Founder, Director, and CSO of Renovos Biologics Limited, a Fellow of the Institute of Biology, and in 2015 was awarded a Doctor of Science degree by the University of Oxford and elected a Fellow of International Orthopaedic Research (FIOR) in 2019. Susanne Wolbank is Head of the Stem Cell Biology Lab and, since 2019, Deputy Director at the Ludwig Boltzmann for experimental and clinical traumatology, Vienna, Austria. She is a biotechnologist (University of Natural Resources and Applied Life Sciences, Vienna) and held a postdoc position at the Clinical Research Center, Karolinska Institutet, Stockholm, on in vitro and in vivo characterization of human embryonic stem cells. She now combines her technological background with her basics knowledge on stem cells to investigate cellular aspects of tissue engineering and regenerative medicine. Her main research interest lies in stem cells from human "waste materials" such as perinatal tissues or adipose tissue. Her work has focused on optimizing these therapeutically relevant cells from isolation to improving the mode of application by activation via shockwave, cell-free application, combination with suitable biomaterials, and characterizing these cells including their interaction with other regenerative cell types. She is the curr

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