Biomedical Aspects of Drug Targeting

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ISBN: 1402072325
ISBN 13: 9781402072321
Herausgeber: Vladimir R Muzykantov/Vladimir P Torchilin
Verlag: Springer Verlag GmbH
Umfang: xvii, 506 S.
Erscheinungsdatum: 28.02.2003
Produktform: Gebunden/Hardback
Einband: GEB

Includes general principles of drug targeting, targeting in the cardiovascular system, tumor targeting, brain targeting, miscellaneous targeting and novel approaches for targeting. This book focuses on ligand-mediated drug targeting strategies, with chapters on general aspects of drug delivery that are of importance in drug targeting.

Artikelnummer: 1587051 Kategorie:

Beschreibung

Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results in low efficiency and unwanted side effects. This concern is even more profound when using highly potent and cytotoxic anticancer drugs or specific agents, such as enzymes and genetic materials, since their effective and safe action requires precise cellular or even sub-cellular addressing in the target organ. To meet safety, efficiency and specificity requirements, drugs somehow must be targeted to the sites of their expected therapeutic action. The idea of the "magic bullet," or drug targeting, proposed by Erlich a century ago, generates great and continuously growing interest in biomedical, industrial and financial circles. This book is focused on the strategies designed to target therapeutic or diagnostic agents to the disease sites. In an attempt to include in this volume the set of chapters reflecting both traditional and emerging areas of drug targeting, we have contacted many leading scientists in the field asking for their contributions. Their responses were most favorable and encouraging. As a result, we have succeeded in assembling a series of outstanding contributions reflecting practically all the key areas of drug targeting. The final structure of this book is as follows.

Inhaltsverzeichnis

Section 1: General Principles of Drug Targeting. 1. Strategies and means for drug targeting: an overview; V.P. Torchilin. 2. Biological barriers for drug targeting; V.R. Muzykantov. Section 2: Cardiovascular Targeting. 3. Targeting the pathological myocardium; Ban-An Khaw. 4. Targeting atherosclerotic plaques; Ban-An Khaw. 5. Thrombus targeting of plasminogen activators and anticoagulants; K. Peter, C. Bode. 6. Tissue-specific pharmacodelivery and overcoming key cell barriers in vivo: vascular targeting of calveolae; L.A. Carver, J.E. Schnitzer. 7. Targeting pulmonary endothelium; V.R. Muzykantov. 8. Targeting inflammation; J.R. Lindner, A.L. Klibanov, K. Ley. 9. Intravascular re-targeting of viral vectors; P.N. Reynolds, S.M. Danilov. Section 3: Tumor Targeting. 10. Polymer-drug conjugates: targeting cancer; R. Duncan. 11. Enhanced permeability and retention (EPR) effect: basis for drug targeting to tumor; H. Maeda. 12. Ligand-directed destruction of tumor vascalature; S. Ran,M. Rosenblum, P.E. Thorpe. 13. Tumor necrosis treatment and imaging of solid tumors; A.L. Epstein,L.A. Khawli, Peisheng Hu. 14. Targeted apoptosis: antibodies linked to RNA damaging agents; S.M. Rybak,M. Arndt, J. Krauss, D.L. Newton, B.K. Vu, Zhongyu Zhu. 15. Immunotoxins and antibody-drug conjugates for cancer treatment; V.S. Goldmacher,W.A. Blättler, J.M. Lambert, R.V.J. Chari. Section 4: Targeting to Brain. 16. Blood-brain barrier transport and drug targeting to the brain; K. Hosoya,S. Ohtsuki, T. Terasaki. 17. LDL-receptor mediated drug targeting to malignant tumors in the brain; R. Sarkar,D.S. Halpern, S.K. Jacobs, D.R. Lu. 18. Targeting brain trauma and stroke; M.A. Petty, Eng H. Lo. 19. Targeting drugs into the central nervous system; L. Prokai. Section 5: Miscellaneous, New Horizons in Targeting. 20. Strategies for targeting infection; J.W. Babich. 21.Anti-HIV immunotoxins; S.H. Pincus, Huang Fa, R. Wilkinson. 22. Ligand-mediated gastrointestinal targeting; J. Woodley. 23. Transmembrane targeting of DNA with membrane active peptides; S. Boeckle, E. Wagner, M. Ogris. 24. Polymersomes: a new platform for drug targeting; D.E. Discher,P. Photos, F. Ahmed, R. Parthasrathy. 25. Targeting mitochondria; V. Weissig, D. D''Souza, V.P. Torchilin. Index.

Autorenporträt

InhaltsangabeSection 1: General Principles of Drug Targeting. 1. Strategies and means for drug targeting: an overview; V.P. Torchilin. 2. Biological barriers for drug targeting; V.R. Muzykantov. Section 2: Cardiovascular Targeting. 3. Targeting the pathological myocardium; Ban-An Khaw. 4. Targeting atherosclerotic plaques; Ban-An Khaw. 5. Thrombus targeting of plasminogen activators and anticoagulants; K. Peter, C. Bode. 6. Tissue-specific pharmacodelivery and overcoming key cell barriers in vivo: vascular targeting of calveolae; L.A. Carver, J.E. Schnitzer. 7. Targeting pulmonary endothelium; V.R. Muzykantov. 8. Targeting inflammation; J.R. Lindner, A.L. Klibanov, K. Ley. 9. Intravascular re-targeting of viral vectors; P.N. Reynolds, S.M. Danilov. Section 3: Tumor Targeting. 10. Polymer-drug conjugates: targeting cancer; R. Duncan. 11. Enhanced permeability and retention (EPR) effect: basis for drug targeting to tumor; H. Maeda. 12. Ligand-directed destruction of tumor vascalature; S. Ran, M. Rosenblum, P.E. Thorpe. 13. Tumor necrosis treatment and imaging of solid tumors; A.L. Epstein, L.A. Khawli, Peisheng Hu. 14. Targeted apoptosis: antibodies linked to RNA damaging agents; S.M. Rybak, M. Arndt, J. Krauss, D.L. Newton, B.K. Vu, Zhongyu Zhu. 15. Immunotoxins and antibody-drug conjugates for cancer treatment; V.S. Goldmacher, W.A. Blättler, J.M. Lambert, R.V.J. Chari. Section 4: Targeting to Brain. 16. Blood-brain barrier transport and drug targeting to the brain; K. Hosoya, S. Ohtsuki, T.Terasaki. 17. LDL-receptor mediated drug targeting to malignant tumors in the brain; R. Sarkar, D.S. Halpern, S.K. Jacobs, D.R. Lu. 18. Targeting brain trauma and stroke; M.A. Petty, Eng H. Lo. 19. Targeting drugs into the central nervous system; L. Prokai. Section 5: Miscellaneous, New Horizons in Targeting. 20. Strategies for targeting infection; J.W. Babich. 21.Anti-HIV immunotoxins; S.H. Pincus, Huang Fa, R. Wilkinson. 22. Ligand-mediated gastrointestinal targeting; J. Woodley. 23. Transmembrane targeting of DNA with membrane active peptides; S. Boeckle, E. Wagner, M. Ogris. 24. Polymersomes: a new platform for drug targeting; D.E. Discher, P. Photos, F. Ahmed, R. Parthasrathy. 25. Targeting mitochondria; V. Weissig, D. D'Souza, V.P. Torchilin. Index.

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