Beschreibung
The efficacy of delavirdine is lower than other FDA approved NNRTIs, therefore, the US department of health and Human Services has recommended its use not as a part of initial therapy but in combination with other drugs. To circumvent this therapeutic difficulty of delavirdine, we amended its structure to develop a novel analogue by replacing its less active indole fragment with a more active anti-HIV prone isatins Mannich bases. The molecular assemblage of delavirdine was concurrently also altered by rearranging its vital fragments to allow it to emerge with altogether a different molecular setting.
Autorenporträt
Dr.Rachna Mishra is Ph.D in Chemistry from Banasthali University, Jaipur - India. She worked on Synthesis of Delavirdine analouges in her research time. She has been engaged in chemistry teaching at institutions in India. Born at Moth, Jhansi - India, She has a great interest in Chemistry and chemical analysis for drugs."Chemistry is Life".
Herstellerkennzeichnung:
BoD - Books on Demand
In de Tarpen 42
22848 Norderstedt
DE
E-Mail: info@bod.de
