Polarity and temporal regulation in bacteriophage Lambda

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54,90 

ISBN: 3659441813
ISBN 13: 9783659441813
Autor: Sodolevsky, Ekaterina
Verlag: LAP LAMBERT Academic Publishing
Umfang: 116 S.
Erscheinungsdatum: 24.05.2018
Auflage: 1/2018
Format: 0.7 x 22 x 15
Gewicht: 191 g
Produktform: Kartoniert
Einband: KT
Artikelnummer: 5203881 Kategorie:

Beschreibung

The Q protein of bacteriophage lambda mediates antitermination in the pR operon and is required for the expression of the late genes of the bacteriophage. Termination at the tR terminator is eliminated in the presence of Q. There are conflicting reports about the action of the Q protein downstream: some investigations show that Q can override terminators while others show that nonsense mutations can lead to polarity, albeit localized. This polarity seems to differ from the classical type because just one or several adjacent genes are affected, but not those further downstream. In the present investigation, it was shown that besides the pR promoter there are no other promoters within the pR operon and all the late genes are transcribed as a single polycistronic mRNA. An amber mutation at the start of the D gene leads to classical genetic polarity that affects all late genes downstream. At the same time, the results show that the morphogenetic genes seem to be organized in temporal modules. The time of expression within such a module is essential for the formation of viable progeny. That is, "localized polarity" takes place at the level of assembly of the phage virion.

Autorenporträt

Ekaterina Sodolevsky received her MSc and PhD degrees in Biology in 2003 and 2007, respectively, from Technion-Israel Institute of Technology. For several years she has worked as a Scientific Director of Southern Poultry Health Laboratory, Egg and Poultry Board.

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