Beschreibung
In the human body kidney is one special organ which is highly terminally differentiated and has very limited capacity to regenerate following injury/ insult. Hence once glomerular diseases set in, they usually progress to end-stage renal disease (ESRD) requiring dialysis or renal transplantation (RT) for better quality of life. However shortage of implantable kidneys and complications of transplantation like immune rejection immunosuppression related morbidity/ mortality, including immunocompromised status, metabolic disorders, infections and malignancies, RT remains a challenge. Therapeutic options available for management of glomerular diseases include symptomatic treatment strategies to delay progression to ESRD. Stem cell-based therapy (SCT) forms recent innovative therapeutic modalities for such diseases due to its ability to inhibit inflammation, replenish dying tissues/ cells and promote regeneration. This review focuses on SCT for treatment of glomerular diseases, including various cell sources used and recent advances in preclinical and clinical studies.
Autorenporträt
Umang G. Thakkar, MBBS, DCH, is currently working as an Associate Professor in the Department of Regenerative Medicine and Cell Therapy at the Institute of Kidney Diseases & Research Centre & Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India.
